Uromax-D Capsule

✔️ Uses of Uromax-D Capsule

• Treat signs and symptoms of Benign Prostatic Hyperplasia (BPH) in men

✔️ How does Uromax-D Capsule work?

Uromax-D Capsule is a combination of two active ingredients, Dutasteride, and Tamsulosin, that work together to alleviate the symptoms of benign prostatic hyperplasia (BPH). Dutasteride inhibits the conversion of testosterone to dihydrotestosterone (DHT), which is responsible for the growth of the prostate gland. Tamsulosin relaxes the muscles surrounding the prostate gland, making it easier for urine to flow through the urethra, and relieves the symptoms of BPH, such as urinary frequency, urgency, and hesitancy. The combined action of these two drugs leads to an improvement in urine flow and a reduction in the size of the prostate gland.

✔️ Side Effects of Uromax-D Capsule

• Impotence
• Decreased Libido
• Ejaculation Disorder
• Orthostatic Hypotension (sudden lowering of blood pressure on standing)
• Breast Enlargement in male
• Breast Tenderness in male

✔️ Quick Suggestions:

• You have been prescribed Uromax-D Capsule relieve the symptoms of benign prostatic hyperplasia (BPH).
• Take it approximately 30 minutes after the same meal each day.
• Uromax-D Capsule may cause dizziness or blurring of vision. Do not drive or do anything requiring concentration until you know how it affects you.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
• If you are scheduled to undergo eye surgery due to cataracts or glaucoma, inform your eye doctor about the usage of the Uromax-D Capsule.
• It may cause difficulty achieving or maintaining an erection (impotence), decreased sex drive, and ejaculation disorders such as the decreased amount of semen produced or decreased sperm count.
• Do not donate blood for 6 months after taking the last dose of Uromax-D Capsule.

✔️ Indication

✔️ Pharmacology

Tamsulosin and Dutasteride are two drugs that are used together to treat Benign Prostatic Hyperplasia (BPH) by targeting different aspects of the condition. Tamsulosin works by blocking certain receptors in the prostate and bladder, causing the muscles in these areas to relax and improving urine flow. It is selective for alpha 1A and alpha 1D receptors, which are found in different concentrations in different tissues. The blocking of alpha 1D receptors in the bladder may also help reduce detrusor overactivity, which can improve urinary function.

Dutasteride, on the other hand, is a drug that inhibits the activity of 5 alpha-reductase, an enzyme that converts testosterone to Dihydrotestosterone (DHT). DHT is known to contribute to the development of BPH, so by reducing its levels, Dutasteride can decrease the size of the prostate and alleviate BPH symptoms. Dutasteride targets both Type I and Type II 5 alpha-reductase isoenzymes, which are overexpressed in BPH tissue compared to normal tissue. Dutasteride does not interact with the androgen receptor.

✔️ Dosage & Administration of Uromax-D Capsule

• For adults, including the elderly, the recommended dose of Tamsulosin-Dutasteride combination medication is one capsule containing Tamsulosin Hydrochloride 0.4 mg and Dutasteride 0.5 mg taken orally once a day, approximately 30 minutes after the same meal each day. This capsule may be used as a substitute for concomitant Tamsulosin Hydrochloride and Dutasteride in existing dual therapy to simplify treatment. In some cases, direct change from Tamsulosin Hydrochloride or Dutasteride monotherapy to this capsule may be considered.
• No adjustment in dosage is expected for patients with renal impairment as the effect of renal impairment on Tamsulosin-Dutasteride pharmacokinetics has not been studied.
• However, caution should be used in patients with mild to moderate hepatic impairment as the effect of hepatic impairment on Tamsulosin-Dutasteride pharmacokinetics has not been studied. In patients with severe hepatic impairment, the use of this capsule is not recommended.

Uromax-D capsules should be taken exactly as prescribed by your physician. You can take the medicine with or without food, but make sure to swallow the tablet whole and not crush or chew it. The appropriate dosage and duration of therapy will be determined by your doctor based on your age, body weight, and medical condition. It is important not to discontinue taking Uromax-D Capsule without informing your doctor first.

✔️ Interaction

Impacts of Dutasteride on the pharmacokinetics of other drugs: Dutasteride is a potent inhibitor of CYP3A4 and CYP3A5 isoenzymes and may increase the serum concentrations of drugs that are substrates for these enzymes, such as midazolam, cyclosporine, and terfenadine. Dutasteride does not inhibit CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, or CYP2D6 isoenzymes at clinically relevant concentrations. Dutasteride does not induce the metabolism of drugs metabolized by CYP450 enzymes.

Impacts of other drugs on the pharmacokinetics of Tamsulosin: Tamsulosin is primarily metabolized by CYP3A4 isoenzyme. The coadministration of potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) with tamsulosin can increase the serum concentrations of tamsulosin and may result in hypotension. The coadministration of tamsulosin with other alpha-blockers may increase the risk of hypotension. The coadministration of tamsulosin with drugs that inhibit CYP2D6 isoenzyme (e.g., fluoxetine, paroxetine) can increase the serum concentrations of tamsulosin.

Impacts of Tamsulosin on the Pharmacokinetics of other drugs: Tamsulosin does not inhibit or induce CYP450 enzymes at clinically relevant concentrations. However, tamsulosin may interact with other drugs that lower blood pressure or affect heart rate, such as nitrates, beta-blockers, calcium channel blockers, or other alpha-blockers, and may increase the risk of hypotension or cardiac side effects.

✔️ Contraindications

Patients with hypersensitivity to Dutasteride, other 5-alpha reductase inhibitors, Tamsulosin (including Tamsulosin-induced angioedema), soya, peanut, or any of the other excipients, patients with a history of orthostatic hypotension, and patients with severe hepatic impairment should not take Tamsulosin-Dutasteride together.

✔️ Pregnancy & Lactation

The combination of Tamsulosin and Dutasteride is not recommended for women. There have been no research on the effects of combining Tamsulosin with Dutasteride on pregnancy, breastfeeding, or fertility. The following claims are based on data from studies involving the individual components. Fertility: In healthy men, dutasteride has been shown to impact sperm parameters (such as sperm count, volume, and motility). Reduced male fertility is a risk that cannot be ruled out. Tamsulosin Hydrochloride has not been studied for its effects on sperm counts or function.

✔️ Precautions & Warnings

• Uromax-D capsules should not be taken by women, children, or adolescents under 18 years of age. It should also be avoided by individuals who are hypersensitive or allergic to the active ingredients, tamsulosin, dutasteride, or any other ingredients in the medicine.
• Avoid or limit alcohol, caffeine, and fizzy drinks: These substances can irritate the bladder and make urinary symptoms worse.
• Limit intake of artificial sweeteners: Some artificial sweeteners can also irritate the bladder and worsen urinary symptoms.
• Maintain a healthy lifestyle and exercise regularly: Maintaining a healthy weight and exercising regularly can help reduce pressure on the bladder and improve urinary symptoms.
• Drink less water in the evening and prior to sleeping: This can help reduce the need to wake up frequently for urination at night.
• Avoid medications that may worsen urinary symptoms: Some medications, such as those used for colds and coughs, can worsen urinary symptoms. Check with your doctor before taking any new medications.
• To avoid pregnancy, fertile males should use a condom during sexual intercourse. Children and teenagers under the age of 18 should not take Uromax-D Capsule. In senior individuals over the age of 65, Uromax-D Capsule should be used with care.
• Uromax-D Capsule may cause some side effects, such as dizziness, headache, fatigue, abnormal ejaculation, decreased libido, and breast tenderness or enlargement in men. These side effects are usually mild and transient, but if they persist or worsen, you should inform your doctor.

✔️ Storage Conditions

Store in a cool, dry place away from sunlight and moisture. Keep it out of reach of children and pets. Do not use expired or damaged medicine, and always dispose of unused or expired medicine properly.